Microdosing with LSD

SUBHEAD: It's a growing phenomena in Silicon Valley. But does it actually work?

By Dominique Mosbergen on 3 September 2018 for Huffington Post -

Image above: Painting titled "St. Albert" by the artist Alex Gray. Dr. Albert Hofmann is the Swiss chemist who discovered LSD, thus catalyzing a consciousness revolution. Surrounding Hofmann in the painting are luminaries who have written about the powerful positive influence of psychedelics. The painting was completed as part of Dr. Albert Hofmann's 100th birthday celebration held in Basel, Switzerland on January 11th, 2006. From (https://shop.cosm.org/collections/artwork) Click to enlarge.

[IB Publisher's note: About friggin' time! It's been 75 years since LSD was discovered. The drug has had a government sponsored propaganda reputation almost as incorrect as that for marijuana. It has taken half a century of my life to get the issue of the usefulness of cannabis/hemp settled. Remember NORML?] 

A powerful distortion and alteration of perception, mood and cognitive function: The effects of taking larger amounts of psychedelic drugs like LSD and magic mushrooms are fairly well documented and understood.

But when it comes to the growing trend of microdosing or taking very small quantities of these drugs on a regular basis, the science is hazy.

Anecdotally, people who microdose with psychedelics have claimed the drugs deliver a range of benefits such as heightened focus, productivity and creativity, as well as psychological and emotional well-being.

The effects are apparently so positive that microdosing has been described as the “life hack du jour” in Silicon Valley, where the practice first gained widespread popularity.

Yet, despite the burgeoning interest in the technique, research into microdosing and its effects remain scarce ― though scientific interest does appear to be growing.

“If you look around in the scientific literature, you realize there are virtually no studies on [this topic],” neuroscience researcher Balazs Szigeti told Wired magazine in a recent interview.

On Monday, Szigeti and a team of colleagues are working to change this fact with the launch of one of the first ever placebo-controlled trials of microdosing.

The study, which is supported by Imperial College London and the Beckley Foundation, a U.K.-based think tank that funds psychedelic research, aims to find out whether microdosing of LSD actually delivers the positive benefits that users claim — or whether it’s merely a placebo effect.

“As a scientist working in the field, it just feels not very satisfying that something explosively used by a lot of people is basically so non-evidence-based,” David Erritzoe, the study’s principal investigator, told Wired.

For cost and feasibility reasons, the study will not be conducted in a lab but will instead involve adult subjects who have been recruited online and who already microdose with LSD or intend to.

The researchers will not provide the drugs but will facilitate a “self-blinding” procedure that will involve sending the participants eight envelopes with QR codes on them.

The subjects will have to fill these envelopes themselves with either empty pills (the placebo) or capsules with LSD microdoses in them.

The participants will then have to mix the eight envelopes up and pick only four of them, each corresponding to one week in the four-week trial.

Once the trial begins, the subjects will take one pill every morning from that week’s envelope ― though they won’t know whether they’re consuming LSD or a dummy pill.

According to the study’s website, participants will be required throughout the study to “complete a set of online questionnaires and to play a selection of online cognitive games.

The questionnaires focus on examining the psychological state of participants, while the online games have been designed to measure cognitive performance.”

As Wired noted, the study has some clear advantages but also inherent problems. “An advantage of the at-home study is that it can accommodate a large number of potential participants, which means more data,” the magazine said.

“A disadvantage, however, is that researchers will have to rely on people following their instructions correctly, reporting back accurately and not breaking the self-blinding mechanism.”

Still, the researchers say they are hopeful that this innovative trial will offer more insight into microdosing’s effects.

“One can’t and doesn’t want to encourage people to microdose, but it is interesting to try to gather data in a slightly more scientific way from people who are doing it,” Amanda Feilding, director of the Beckley Foundation, told The Guardian of the new research.

See also:
Ea O Ka Aina: Be Your Own Medicine 1/31/16
Ea O Ka Aina: Deadhead Security Alert
Ea O Ka Aina: 10 Things about Steve Jobs 8/24/11
Ea O Ka Aina: Psychedelics are "Born Illegal"
Ea O Ka Aina: Fear and Loathing in America 1/20/06

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